Floresville is a city in Wilson County, Texas, United States. The population was 6,448 at the 2010 census. It is the county seat of Wilson County. The city is also part of the San Antonio Metropolitan Statistical Area.Floresville was the birthplace and hometown of former Secretary of the Navy, Democratic Texas Governor, United States Secretary of the Treasury, and Republican presidential contender John Bowden Connally, Jr., and his seven siblings, including actor Merrill Connally and Wayne Connally, a former member of both houses of the Texas State Legislature. The Connally Memorial Medical Center in Floresville is named for John, Merrill, and Wayne Connally.Floresville was also the birthplace of Vicente T. Ximenes, a former member of the Equal Employment Opportunity Commission and a civil rights activist.